R&D  |  논문

저분자 신약, 뇌질환 치료제, 신약 개발 의약화학 개발 전문가가
난치성 뇌질환 치료제 신약 개발을 위해 뜻을 모아 시작하였습니다.

R&D  |  논문

저분자 신약, 뇌질환 치료제, 신약 개발 의약화학
개발 전문가가 난치성 뇌질환 치료제 신약 개발을 위해
 뜻을 모아 시작하였습니다. 

| 2024

CV-04  2.4 상위(4.0%)

Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease

Theranostics


CV-04  6.0(상위10.4%)4

"Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders"

European Journal of Medicinal Chemistry


CV-01  6.9 (상위3.5%)

Discovery and Optimization of a Series of Vinyl Sulfoximine-Based Analogues as Potent Nrf2 Activators for the Treatment of Multiple Sclerosis

European Journal of Medicinal Chemistry

| 2023

CV-02  6.9 (상위3.5%)

Exploration of Tetrahydroisoquinoline- and Benzo[ c]azepine-Based 1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis

Journal of Medicinal Chemistry


CV-01  2.4 상위(4.0%)

Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects

European Journal of Medicinal Chemistry

| 2022

CV-02  2.4 상위(4.0%)

Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis

European Journal of Medicinal Chemistry

| 2021

CV-01  6.0(상위10.4%)

Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease

European Journal of Medicinal Chemistry

| 2020

CV-01  6.0(상위10.4%)

A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

Theranostics

| 2019

CV-01  6.9(상위3.5%)

Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Erythroid 2

‑Related Factor 2 (Nrf2) Activators for Parkinson’s Disease Therapy

Journal of Medicinal Chemistry


CV-01  3.5

Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator

ACS Medicinal Chemistry Letters

| 2014

CV-01  6.9(상위3.5%)

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy

Journal of Medicinal Chemistry

No

게제 연도

논문명

저널명

IF(%)

파이프라인


11

   2024

Highly potent and selective PPARδ agonist reverses memory deficits

in mouse models of Alzheimer's disease

Theranostics

2.4 상위(4.0%)

CV-04    


10

   2024

"Discovery of the therapeutic potential of PPARδ agonist bearing

1,3,4- thiadiazole in inflammatory disorders"

6.0(상위10.4%)

CV-04    


9

   2024

Discovery and Optimization of a Series of Vinyl Sulfoximine-Based

Analogues as Potent Nrf2 Activators for the Treatment of Multiple Sclerosis

6.9 (상위3.5%)

CV-01    


8

   2023

Exploration of Tetrahydroisoquinoline- and Benzo[ c]azepine-Based

1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis

6.9 (상위3.5%)

CV-02    


7

   2023

Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator

for the antioxidant and anti-inflammatory effects

6.9 (상위3.5%)

CV-01    


6

   2022

Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists

for the Treatment of Multiple Sclerosis

2.4 상위(4.0%)

CV-02    


5

   2021

Development and optimization of halogenated vinyl sulfones as

Nrf2 activators for the treatment of Parkinson’s disease

6.0(상위10.4%)

CV-01    


4

   2020

A novel chalcone derivative as Nrf2 activator attenuates learning

and memory impairment in a scopolamine-induced mouse model

Theranostics

6.0(상위10.4%)

CV-01    


3

   2019

Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Erythroid 2

‑Related Factor 2 (Nrf2) Activators for Parkinson’s Disease Therapy

6.9(상위3.5%)

CV-01    


2

   2019

Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator

3.5

CV-01    

Right Structure
& Value Creation

 저분자 신약 개발의 새로운 역사를 만들다.


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